Dr. Joseph R. Lakowicz

	Dr. Joseph R. Lakowicz, Professor	Center for Fluorescence Spectroscopy 725 West Lombard Street Baltimore, MD 21201 410-706-7978


My research is focused on advancing the field of fluorescence spectroscopy. This involves chemical synthesis of new fluorophores, development of novel fluorescence measurements, development of instrumentation for time-resolved fluorescence, and the chemical applications of fluorescence sensing. Much of this work has resulted in inventions, patents and licensing. My laboratory is also involved in the more advanced topics of multi-photon excitation, in which molecules are excited by the simultaneous absorption of two or more long wavelength photons. Additionally, work is being done on the use of light pulses to control the excited state population and orientation.	Dr. Joseph R. Lakowicz, Professor University of Maryland School of Medicine Director, Center for Fluorescence Spectroscopy phone: 410-706-7978 fax: 410-706-8408 Contact by e-mail Professional Experience 1984-present: Professor, Department of Biochemistry and Molecular Biology, University of Maryland at Baltimore, School of Medicine 1993-present: Adjunct Professor, Electrical Engineering, University of Maryland, Baltimore County 1988-present: Senior Staff Scientist, Medical Biotechnology Center, University of Maryland at Baltimore 1988-present: Director, Center for Fluorescence Spectroscopy, University of Maryland School of Medicine, Department of Biochemistry and Molecular Biology 1989-1993: Head, Molecular Graphics Facility, University of Maryland School of Medicine 1980-1984: Associate Professor, Department of Biological Chemistry, University of Maryland at Baltimore, School of Medicine 1975-1980: Assistant Professor of Biochemistry, Department of Biochemistry and Gray Freshwater Biological Institute, University of Minnesota. Promoted to Associate Professor with tenure, effective July 1980 1974-1975: Research Associate, Freshwater Biological Institute, University of Minnesota 1973-1974: Postdoctoral Fellow, Oxford University, Department of Biochemistry, Oxford, England, Nuclear Magnetic Resonance Professional Activities Author, Principles of Fluorescence Spectroscopy, 3^rd edition Founding Editor-in-Chief Journal of Fluorescence Journal of Biomedical Optics Co-Editor-in-Chief Plasmonics Topics in Fluorescence Spectroscopy Co-Founding Editor Annual Reviews in Fluorescence Over 500 peer-reviewed publications	Principles of Fluorescence Spectroscopy 3^rd edition Specialties: Fluorescence Spectroscopy Fluorescence Resonance Energy Transfer, Frequency-domain, Time-resolved fluorescence, polarization, anisotropy decays, Metal-enhanced fluorescence, Plasmonics and fluorescence, Single molecule detection, sensing, clinical chemistry, analytical chemistry

Consulting on Fluorescence	Representative Publications Directional Surface Plasmon Coupled Emission, Geddes, C. D., Gryczynski, I., Malicka, J., Gryczynski, Z., and Lakowicz, J. R. (2004). J. Fluoresc., 14(1):119-123 Fluorescence Spectral Properties of Indocyanine Green on a Roughened Platinum Electrode Metal-Enhanced Fluorescence, Geddes, C. D., Parfenov, Z., Roll, D., Uddin. Md. J., and Lakowicz, J. R. (2003). J. Fluoresc., 13(6):453-457. Radiative Decay Engineering 3. Surface Plasmon-Coupled Directional Emission, Lakowicz, J. R. (2004). Anal. Biochem., 324:153-169. Radiative Decay Engineering 4. Experimental Studies of Surface Plasmon Coupled Directional Emission, Gryczynski, I., Malicka, J., Gryczynski, Z., and Lakowicz, J. R. (2004). Anal. Biochem., 324:170-182. Aggregation of Silver Nanoparticle-Dextran with Concanavalin A and Competitive Complexation with Glucose, Zhang, Z., Roll, D., Geddes, C. G., and Lakowicz, J. R. (2004). J. Phys. Chem. B., 108:12210-12214. Ultraviolet Surface Plasmon-Coupled Emission Using Thin Aluminum Films, Gryczynski, I., Malicka, J., Gryczynski, Z., Nowaczyk, K., and Lakowicz, J. R. (2004). Anal. Chem., 76:4076-4081. Oligonucleotide Displaced Organic Monolayer-Protected Silver Nanoparticles and Enhanced Luminescence of Their Salted Aggregates, Zhang, J., Malicka, J., Gryczynski, I., and Lakowicz, J. R. (2004). Anal. Biochem., 330:81-86. Fluorescence Spectral Properties of Labeled Thiolated Oligonucleotides Bound to Silver Particles, Malicka, J., Gryczynski, I., and Lakowicz, J. R. (2004). Biopolymers, 74:263-271. First Observation of Surface Plasmon-Coupled Electro-chemiluminescence, Zhang, J., Gryczynski, Z., and Lakowicz, J. R. (2004). Chem. Phys. Letts., 393:483-487. Effects of Sample Thickness on the Optical Properties of Surface Plasmon Coupled Emission, Gryczynski, I., Malicka, J., Nowaczyk, K., Gryczynski, K., and Lakowicz, J. R. (2004). J. Phys. Chem., 108:12073-12083. Saccharide Sensing Using Gold and Silver Nanoparticles, Aslan, K., Zhang, J., Lakowicz, J. R., and Geddes, C. D. (2004). J. Fluoresc., 14(4):391-408. Immunoassays Based on Directional Surface Plasmon-Coupled Emission, Matveeva, E., Gryczynski, Z., Gryczynski, I., and Lakowicz, J. R. (2004). J. Immunol. Methods, 286:133-140. Surface Plasmon-Coupled Emission with Gold Films, Gryczynski, I., Malicka, J., Gryczynski, Z., and Lakowicz, J. R. (2004), J. Phys Chem. B., 108:12568-12574. Aggregation of Silver Nanoparticle-Dextran Adducts with Concanavalain A and Competitive Complexation with Glucose, Zhang, J., Roll, D., Geddes, C. D., and Lakowicz, J. R. (2004). J. Phys. Chem. B., 108:12210-12214. more>>	Center for Fluorescence Spectroscopy