Dr. Michael L. Johnson brings the project 30+ years of experience in mathematical modeling of biomedical systems. Johnson is also involved in the mathematical modeling of many other biomedical systems such as growth patterns in children, cognitive performance as a function of sleep, mechanisms of cooperativity in oxygen binding to hemoglobin, and the analysis of fluorescence lifetime data. Johnson has been affiliated with the University of Virginia (UVA) as a biomathematician since joining the faculty in 1979. Johnson is a Professor of Pharmacology and a Professor of Internal Medicine (in the Division of Endocrinology and Metabolism), both in UVA’s Health System, with a Ph.D. in biophysics (University of Connecticut, 1974), specializing in modeling of biological processes. Johnson has authored more than 300 publications and has been editor of twelve books, the majority of which involve mathematical modeling of various biological processes (for example, Methods in Enzymology volumes 210, 240, 321, 383 and 384 on "Numerical Computer Methods," Methods in Enzymology volumes 259, 295, 323, 379, and 380 on "Energetics of Biological Macromolecules," Methods in Neuroscience volume 28 on "Quantitative Neuroendocrinology, and Methods in Enzymology volume 278 on "Fluorescence Spectroscopy" ). Additionally, Johnson is the biomathematician for the UVA General Clinical Research Center, the only biomathematician on the staff of any of the NIH General Clinical Research Centers. He is also the Associate Director of the Ligand Assay Core of the UVA Center for Reproduction and a co-founder of the UVA Center for Biomathematical Technology.