Jian Zhang
Experience:
Assistant Professor, Center for Fluorescence Spectroscopy, School of Medicine, University of Maryland at Baltimore, 2003.
Postdoctor Fellow, University of North Carolina at Chapel Hill, 2001-2003.
Postdoctor Fellow, North Carolina State University, 1999-2000.
Ph.D., Ibaraki University of Japan, 1999.
Research Associate, Institute of Chemistry, Chinese Academy of Sciences, 1991-1994.
MS, Institute of Chemistry, Chinese Academy of Sciences, 1991.
BS, Beijing Normal University of China, 1986.
Research Interest: bioanalytical chemistry, physical chemistry, and nanoscience.
My research interests focus on the biological detection including carbohydrate, DNA, and protein using fluorescence spectra. We find that the fluorescence can be enhanced when the fluorophore is localized near the surface of metal particle and the enhancement is dependent on the features of particle such as size, shape, charge state, and aggregation, etc., as well as other factors like distance of fluorophore to metal surface and wavelength of fluorophore, etc. We prepare the nano-scale metal materials capped on the solid substrate or dispersed in solution by synthesis, vapor deposition, electrochemistry, lithography, and LB, etc, which are used to study the surface enhanced fluorescence (SEF). The SEF technique is used to study the biological detection.
Hobby: reading book and playing basketball.
Selected publications:
Zhang, J.; Geddes, C. D.; Lakowicz, J. R. Complexation of polysaccharide and monosaccharide with thiolate boronic acid capped on silver nanoparticle, Analytical Biochemistry 2004, 332, 253-260.
Zhang, J.; Roll, D.; Geddes, C. D.; Lakowicz, J. R.
Aggregation of silver nanoparticle-dextran adducts with concanavalin A and competitive complexation with glucose, Journal of Physical Chemistry B 2004, 104,12210-12214.Zhang, J.; Gryczynski, Z.; Lakowicz, J. R. First observation of surface plasmon-coupled electrpchemiluminescence, Chemical Physics Letter 2004, 393, 483-487.
Zhang, J.; Malicka, J.; Gryczynski, I.; Lakowicz, J. R. Oligonucleotide-displaced organic monolayer-protected silver nanoparticles and enhanced luminescent of their salted aggregates Analytical Biochemistry 2004, 330, 81-86.
Zhang, J.; Lee, J.K.; Wu, Y.; Murray, R.W. Photoluminescence and electronic interaction of anthracene derivatives adsorbed on sidewalls of single-walled carbon nanotubes, Nano Letters 2003, 3, 403-407.
Zhang, J.; Whitesell, J.K.; Fox, M. A. Photophysical behavior of variously sized colloidal gold clusters capped with monolayers of an alkylstilbenethiolate, Journal of Physical Chemistry B 2003, 107, 6051-6055.
Zhang, J.; Wang, G.; Shon, Y.-S.; Zhou, O.; Superfine, R.; Murray, R. W. Interactions of small molecules and Au nanoparticles with solubilized single-wall carbon nanotubes, Journal of Physical Chemistry B 2003, 107, 3726-3732.
Wang, G; Zhang, J.; Murray, R.W. DNA Binding of an Ethidium Intercalator Attached to a Monolayer-Protected Gold Cluster, Analytical Chemistry 2002, 74, 4320-4327.
Zhang, J.; Whitesell, J.K.; Fox, M. A. Photoreactions of a self-assembled monolayer of azobenzene or stilbene derivatives capped on colloidal gold clusters, Chemistry of Materials 2001, 13, 2323-2331.
Hu, J.; Zhang, J.; Liu, F.; Kittredge, K; Whitesell, J.K.; Fox, M.A. Competitive photochemical reactivity in a self-assembled monolayer on colloidal gold, Journal of American Chemical Society 2001, 123, 1464-1470.